FSH is crucial in maintaining the normal function of the male and female reproductive systems.
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This test can also be purchased as part of our Women’s Hormone panel.
PREPARATION: No fasting or other special preparation is needed for this test. However, there are many factors that can affect the outcome of this test, so please read the following carefully:
Taking birth control pills or hormone supplements that contain testosterone, estrogen, or progesterone can affect the results of the Follicle Stimulating Hormone (FSH) test, and you should ask your treating physician whether and/or when you should stop taking this medicine prior to performing this test.
The FSH test result may also be affected by some medications including cimetidine, clomiphene, digitalis, and levodopa. The radioactive substances used in nuclear imaging tests can also interfere with FSH levels, so you should speak with your doctor before having this test if you have had a recent thyroid scan, bone scan, or other study that used a radioactive dye.
What does this test do?
This test determines the concentration of follicle-stimulating hormone circulating in the bloodstream.
Why is this important?
Follicle stimulating hormone (FSH) is produced by a part of the brain called the pituitary gland. It works together with another messenger called Luteinizing hormone, and both have extremely important effects on both male and female sexual development as well as reproductive physiology.
In women, FSH helps control the menstrual cycle and the production of eggs by the ovaries. In men, FSH helps control the production of sperm.
Measuring the amount of FSH can be useful in evaluating the functions of the sex organs, and is often used to help ascertain potential causes of infertility in both men and women.
This test is also used in evaluating pituitary gland function, and to help diagnose the cause of early (precocious) or delayed puberty in children.
What do the results mean?
The range of FSH levels considered to be normal is variable, and depends on several factors including the person’s age and stage of sexual development at the time the testing is performed.
Once men have reached adulthood the amount of FSH usually remains constant. A low value is a sign that the pituitary gland is not functioning properly, and can be the cause of a low sperm count. An elevated level of FSH can be seen with certain pituitary gland tumors, or result from a loss of testicular function.
In women who haven’t reached menopause the blood level of FSH varies significantly throughout the menstrual cycle, so it is important to know the first day of the last menstrual period before the test is performed.
The FSH level increases rapidly to reach its highest concentration just before ovulation occurs, which is about midway through the cycle (e.g. day 14 of a 28-day cycle). When used in treating infertility, the FSH test can be repeated several times to help pinpoint the exact time of ovulation, which is when the ovary releases an egg.
FSH levels that remain persistently high indicate a condition called “primary ovarian failure,” where the ovaries aren’t functioning properly. Elevated levels of FSH can also be seen produced by certain pituitary gland tumors.
In contrast, persistently low levels of FSH may be a sign of “secondary ovarian failure,” which suggests a problem with the pituitary gland. This is frequently found as a cause of infertility because this can lead to a decreased egg supply in women.
The FSH test is also performed when a boy or girl has not entered puberty as expected, or appears to be entering puberty early. Low levels are found in the delayed onset of puberty, and high levels are linked to early onset (or precocious) puberty.