Estradiol is the primary estrogen hormone responsible for normal female development.
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This test can also be purchased as part of our Women’s Hormone panel.
PREPARATION: No fasting or other special preparation is needed for this test.
What does this test do?
This test determines the concentration of estradiol circulating in the bloodstream.
Why is this important?
Estradiol is the major estrogen hormone found in humans. It is produced by the ovaries in women, and by the testicles in men.
In adult women, estradiol is the primary female sex hormone, where it plays a crucial role in regulating the menstrual cycle. As such, measuring the blood levels of estradiol can be used to investigate menstrual abnormalities such as lack of menstrual periods (amenorrhea), or abnormal vaginal bleeding. Estradiol levels are also used during infertility treatment, to help determine ovarian function as well as to monitor follicular development.
In girls, estradiol is also useful in diagnosing early-onset or delayed puberty. It is also used to detect estrogen-producing tumors, as well as to monitor the effectiveness of anti-estrogen therapy used to treat breast cancer.
What do the results mean?
In women, high estradiol levels are found in pregnancy, and during infertility treatment when trying to induce ovulation.
Decreased estradiol levels in females may result from either ovarian failure (primary ovarian hypofunction in young girls who fail to reach puberty, and after menopause in older women), or from a problem in the hypothalamus-pituitary hormonal loop (secondary ovarian hypofunction).
In adolescent boys, elevated estradiol levels may be found in cases of delayed puberty, and in men are often associated with enlarged breasts (gynecomastia). Estradiol levels are also often monitored in men receiving supplemental testosterone therapy.